Journal article
Gradual aeration at birth is more lung protective than a sustained inflation in preterm lambs
DG Tingay, PM Pereira-Fantini, R Oakley, KE McCall, EJ Perkins, M Miedema, M Sourial, J Thomson, A Waldmann, RL Dellaca, PG Davis, PA Dargaville
American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2019
Abstract
Rationale: The preterm lung is susceptible to injury during transition to air breathing at birth. It remains unclear whether rapid or gradual lung aeration at birth causes less lung injury. Objectives: To examine the effect of gradual and rapid aeration at birth on: 1) the spatiotemporal volume conditions of the lung; and 2) resultant regional lung injury. Methods: Preterm lambs (125±1 d gestation) were randomized at birth to receive: 1) tidal ventilation without an intentional recruitment (no-recruitment maneuver [No-RM]; n = 19); 2) sustained inflation (SI) until full aeration (n = 26); or 3) tidal ventilation with an initial escalating/de-escalating (dynamic) positive end-expiratory press..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
Supported by a National Health and Medical Research Council Project Grant (1009287) and the Victorian Government Operational Infrastructure Support Program (Melbourne, Victoria, Australia), a National Health and Medical Research Council Clinical Career Development Fellowship (1053889; D.G.T.), and a National Health and Medical Research Council Program Grant (606789) and a National Health and Medical Research Council Practitioner Fellowship (556600; P.G.D.). Chiesi Farmaceutici S.p.A. provided the Curosurf used in this study as part of an unrestricted grant (D.G.T.) at the Murdoch Childrens Research Institute.